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Pharmacokinetics

Quantitative measurements of ADME properties provide valuable information on the bioavailability of your compound and are essential for the design of preclinical pharmacological and toxicological studies.

We offer in vitro metabolism service with CYP450 induction and inhibition, Phase II metabolism and metabolic stability, in compliance with GLP Principles.

Pharmacokinetics studies are conducted in rodents (mice or rat) to determine the bioavailability and plasma clearance (IV administration vs clinical expected route). The main pharmacokinetics parameters are calculated, as terminal halflife (t1/2), maximum plasma concentration (Cmax) and sampling time of Cmax (tmax), area under the concentration-time curve from dosing time to infinity (AUC), area under the concentration-time curve from dosing time to tlast (AUC0-tlast), and absolute bioavailability (F).

We provide end-to-end pharmacokinetics studies including validation of bioanalytical methods, vehicle finding and stability testing, in-life part in rodent and non-rodent species, plasma/serum analysis, urine and faeces collection in metabolic cages, tissue homogenate analysis and bioavailability in addition to the pharmacokinetics calculations.

We routinely provide pharmacokinetic studies in mouse, rat, hamster, guinea pig, and help you to choose the correct species for the pharmacokinetics studies.

Available dose routes include:

  • intravenous (IV)
  • oral (PO)
  • subcutaneous (SC)
  • intradermal (ID)
  • intraperitoneal (IP)
  • intramuscular (IM)
  • sub lingual (SL)

Formulation for IV dosing:

  • Vehicle finding
  • Vehicle stability

We collect different matrices, including plasma/serum/whole blood, and solid tissues (liver, lungs, brain, heart, muscle, testis etc.). Bioanalysis is possible from all of these matrices. In oncology studies, the matrix can also be the tumor tissue.
We also routinely collect urine and feces by conducting the studies in metabolic cages with an ability to immediately chill the released excrements (rat).